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School of Engineering

Pharmaceutical Chemistry Group

(GQF)

The GQF group research focuses on two main areas:

 

1) The Pharmaceutical Chemistry Unit (new drugs): pharmaceutical and cosmetics formulation, applied biology and API production within the areas of Biomedicine and Health Sciences.

 

2) The Continuous Chemical Processes Unit: application of new advanced manufacturing technologies in fine chemistry, to transform and optimise production systems from batch to continuous, making them more efficient, more stable, safer, faster and cleaner.

 

This range of services is offered through the use of the unit’s continuous reaction equipment: the Syrris ASIA reactor for small trials, and the TITAN for scale-up and production of small batches, in the order of a kilo of product. The Process Analytical Technologies (PAT) allow the continuous monitoring of the processes and guarantee the quality of their results.

In this environment, GQF carries out its R&D and technology transfer activities in the following areas:

  • Tyrosine kinase inhibitors with application for cancer (lung, breast and pancreatic)
  • Compounds with activity against chemokine-like receptors (CXCR4 inhibitors)
  • Compounds with activity against myotonic dystrophy
  • Screening and selection of chemical reactions, with the help of microwave reactors
  • Laboratory tests for the development of new processes or for the improvement of existing ones
  • Process optimisation by design of experiments (DoE)
  • Scale-up of new or existing processes
  • Small batch production

COORDINATOR:

José I. Borrell Bilbao, PhD

Head of GQF Group - Professor
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MEMBERS:

Beatriz Artalejo Ortega, PhD

GMP Technical Management
+34932672000

Xavier Batllori Aguilá, PhD

Head of Spectroscopy Laboratory
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Ana Belén Cuenca González, PhD

Associate Professor - Head of Organic and Pharmaceutical Chemistry Dpt.
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Eduard Serra Hosta, PhD

Head of Thermal Analysis Laboratory - Assistant Professor
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Jordi Teixidó Closa, PhD

Academic Organisation and Quality. Vice-Rector URL - Head of Molecular Design Lab. - Professor
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EXTERNAL COLABORATORS

Santiago Ramon y Cajal, PhD

Hospital Vall d'Hebron

Gaël Roué, PhD

Hospital Vall d'Hebron

FACILITIES

Flow Chemistry Unit

Spectroscopy Laboratory

Thermal Analysis Laboratory

LINKED NEWS

Research

Fighting Against Emerging Drugs

16/03/2022
IQS participates in the European project NEXTGenPS, with the aim of detecting addictive and potentially hallucinogenic substances and facilitating the implementation of control measures for them in the European Union.
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Research

New Synthesis Challenges. BISiboNds Project

21/01/2022
Researchers from IQS and IQAC are working together on the development of new synthetic methodologies where they explore the combined use of catalytic systems with the great versatility of chemical elements such as Boron, Iodine and Silicon.
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7 Questions for...

Beatrice Ravasio

05/03/2021
Beatrice is a doctoral Student in Industrial Engineering with the Department of Chemical Engineering and Materials Science at the IQS School of Engineering.
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News

Continuous Chemical Processes Unit. Services for industry

05/03/2021
The offer of R&D&i services that IQS Tech Transfer provides companies has been expanded since 2020 with the launch of the Continuous Chemical Processes Unit, installed in the CTPTI at IQS, which is aimed at improving fine chemistry processes to make them safer, faster, and cleaner.
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News

Continuous Chemical Processes Unit. Auxiliary analytical services.

05/03/2021
With Process Analytical Technology (PAT), it is possible to monitor the reactions that take place in the Flow Chem Unit reactors. Moreover, any substance or mixture can be characterized with the equipment in the Thermal Analysis Laboratory (DSC and TGA).
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News

Continuous Chemical Processes Unit. Facilities and Equipment

04/03/2021
The facilities and equipment at the CTPTI Continuous Chemical Processes Unit make it possible to apply new advanced manufacturing technologies in fine chemicals, which opens up the possibility of comprehensively developing safer, faster, and cleaner chemical processes.
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Editorial

Continuous Chemical Processes Unit

04/03/2021
Through the publication and dissemination of this special issue dedicated to the Continuous Chemical Processes Unit, we would like to present the facility, the equipment and instruments that comprise it, the various services that we can offer to industry, and the excellent personnel without whom the project would not be a reality.
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LATEST PROJECTS

DisX4lymph (Interrupción de la interacción estroma-tumor en linfoma B utilizando inhibidores CXCR4 y degradadores IRAK4)

Diseño y síntesis de inhibidores alostéricos de CXCR4 y degradadores de IRAK4 como potencial tratamiento de linfoma de células B.
Funding Agency:
Research Group Link:
Pharmaceutical Chemistry Group (GQF)

NanoPan-3D (Desarrollo de nuevos nano-vehículos para superar la resistencia a fármacos del adenocarcinoma pancreático y su validación mediante modelos celulares 3D mixtos)

Nanoterapia para superar la resistencia a fármacos del adenocarcinoma pancreático.
Funding Agency:
Research Group Link:
Pharmaceutical Chemistry Group (GQF)
Materials Engineering (GEMAT)

NextGenPS (Farmacovigilancia de sustancias psicoactivas)

Detección temprana y efectiva del potencial adictivo y alucinógeno en la siguiente generación de fármacos psicoactivos para acelerar la implementación de medidas de control en la Unión Europea.
Funding Agency:
Research Group Link:
Pharmaceutical Chemistry Group (GQF)
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