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Theranostic photosensitizers (Phosphorescence-guided surgery combined with photodynamic therapy)

Photodynamic therapy uses harmless light in live cells and animal to activate non- toxic photosensitive chemicals photosensitizers to generate cytotoxic species for malignant cell eradication (cancer cells, bacterial infections).

Funding Sources:
Government of Catalonia
Funding Agency:
Type of Project:
Individual project
Period:
01/07/2022 a 01/07/2025
Funding:
144.300€
Project current status:
COMPLETED

This project will explore the concept of theranostic agents to demonstrate its utility in the Photodynamic therapy (PDT) field and convince the medical community to include PDT as a common clinical treatment against a wide variety of diseases such as virus, bacterial or fungi infections and cancer.

The project is based on the concept that it should be possible to use the same light to induce the death of the cancer cells or pathogenic bacteria, and simultaneously measure the amount of ROS generated to avoid unnecessary damage to the surroundings tissues or visualize the remaining tumor cells after the surgery treatment to completely eradicate them. The resesarcher working in this Beatriu de Pinos Fellowship is Dr. Roger Bresolí under the supervision of Dr. Santi Nonell.

PRIMARY INVESTIGATOR

Roger Bresolí Obach, PhD

Associate Professor - Researcher Ramón y Cajal
+34932672000
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LINKED NEWS

Interview

Theranostic Photosensitizing Agents for Phosphorescence-Guided Surgery

30/09/2022
"It is essential to have adequate tools in order to study complex systems, and photonics is an ideal discipline considering its non-invasive nature, occupying an essential place in research"
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RESEARCH GROUP

AppLightChem

Applied Photobiological Chemistry

School of Engineering

Applied Photobiological Chemistry

Specialised research in biomedical applications (antimicrobial resistance with phototherapy) and development of theragnostics in the diagnosis and treatment of tumours.